Simon, Dorottya Anna ; Tálas, András ; Kulcsár, Péter István ; Biczók, Zsuzsanna ; Krausz, Sarah Laura ; Várady, György ; Welker, Ervin
PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells
ELIFE 11 Paper: e69504 , 19 p. (2022)
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Article (Journal Article)
Extract: The paper presents a new tool called PEAR (Prime Editor Activity Reporter). This reporter system allows researchers to visually identify cells that have been successfully prime edited. The study demonstrates how PEAR can enhance the efficiency of prime editing by enabling the selective enrichment of edited cells. This tool is adaptable for a wide range of genetic modifications, improving the precision and effectiveness of genome editing applications.

Tálas, András ; Simon, Dorottya Anna ; Kulcsár, Péter István ; Varga, Éva ; Krausz, Sarah Laura ; Welker, Ervin
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors
NATURE COMMUNICATIONS 12 : 1 Paper: 6353 , 14 p. (2021)
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Article (Journal Article)