Publications
Names in blue indicate current and former members of the Welker Lab.
No Data Found
2025
2023
Huszár, Krisztina ; Welker, Zsombor ; Györgypál, Zoltán ; Tóth, Eszter; Ligeti, Zoltán ; Kulcsár, Péter István ; Dancsó, János ; Tálas, András ; Krausz, Sarah Laura ; Varga, Éva ; Welker, Ervin
Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs
NUCLEIC ACIDS RESEARCH 51 : 11 pp. 5847-5863. , 17 p. (2023)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
Kulcsár, Péter István ; Tálas, András ; Ligeti, Zoltán ; Tóth, Eszter ; Rakvács, Zsófia ; Bartos, Zsuzsanna ; Krausz, Sarah Laura ; Welker, Ágnes ; Végi, Vanessza Laura ; Huszár, Krisztina ; Ervin Welker
A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets
NATURE COMMUNICATIONS 14 : 1 Paper: 5746 , 20 p. (2023)
DOI WoS Scopus PubMed
Article (Journal Article)
2022
Kulcsár, Péter István ; Tálas, András ; Ligeti, Zoltán ; Krausz, Sarah Laura ; Welker, Ervin
SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e
NATURE COMMUNICATIONS 13 : 1 Paper: 6858 , 11 p. (2022)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
Simon, Dorottya Anna ; Tálas, András ; Kulcsár, Péter István ; Biczók, Zsuzsanna ; Krausz, Sarah Laura ; Várady, György ; Welker, Ervin
PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully primed edited cells
ELIFE 11 Paper: e69504, 19 p. (2022)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
2021
Dondapati, Divya Teja ; Cingaram, Pradeep Reddy ; Ayaydin, Ferhan ; Nyeste, Antal ; Kanyo, Andor ; Welker, Ervin ; Fodor, Elfrieda
Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin
MEMBRANES (BASEL) 11 : 12 Paper: 978 , 31 p. (2021)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
Sangeetham, Sangeetham Babu ; Engelke, Anna Dorothee ; Fodor, Elfrieda ; Krausz, Sarah Laura ; Tatzelt, Jörg; Welker, Ervin
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo
SCIENTIFIC REPORTS 11 : 1 Paper: 3116 , 13 p. (2021)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
Tálas, András ; Simon, Dorottya Anna ; Kulcsár, Péter István ; Varga, Éva ; Krausz, Sarah Laura ; Welker, Ervin
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors
NATURE COMMUNICATIONS 12 : 1 Paper: 6353 , 14 p. (2021)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
Tálas, András ; Huszár, Krisztina ; Kulcsár, Péter István ; Varga, Julia K ; Varga, Éva ; Tóth, Eszter ; Welker, Zsombor; Erdős, Gergely ; Pach, Péter Ferenc ; Welker, Ágnes ; Györgypál, Zoltán ; Tusnády, Gábor ; Welker, Ervin
A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs
NUCLEIC ACIDS RESEARCH 49 : 6 Paper: e31 , 12 p. (2021)
DOI WoS REAL Scopus PubMed
Article (Journal Article)
2020
Kulcsár, Péter István ; Tálas, András ; Tóth, Eszter ; Nyeste, Antal ; Ligeti, Zoltán ; Welker, Zsombor ; Welker, Ervin
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs
NATURE COMMUNICATIONS 11 : 1 Paper: 1223 , 14 p. (2020)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
Tóth, Eszter ; Varga, Éva ; Kulcsár, Péter István ; Kocsis-Jutka, Virág; Krausz, Sarah Laura ; Nyeste, Antal ; Welker, Zsombor ; Huszár, Krisztina ; Ligeti, Zoltán ; Tálas, András ; Welker, Ervin
Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases
NUCLEIC ACIDS RESEARCH 48 : 7 pp. 3722-3733. , 12 p. (2020)
DOI REAL WoS Scopus PubMed Other URLs
Article (Journal Article)
2018
Sangeetham, Sudheer Babu ; Huszár, Krisztina ; Bencsura, Petra ; Nyeste, Antal ; Hunyadi-Gulyas, Éva ; Fodor, Elfrieda ; Welker, Ervin
Interrogating the Dimerization Interface of the Prion Protein Via Site-Specific Mutations to p-Benzoyl-L-Phenylalanine
JOURNAL OF MOLECULAR BIOLOGY 430 : 17 pp. 2784-2801. , 18 p. (2018)
DOI WoS REAL Scopus PubMed Other URLs
Article (Journal Article)
Tóth, Eszter ; Czene, Bernadett C ; Kulcsár, Péter István ; Krausz, Sarah Laura ; Tálas, András ; Nyeste, Antal ; Varga, Éva ; Huszár, Krisztina ; Weinhardt, Nóra ; Ligeti, Zoltán ; Borsy, Adrienn Éva ; Fodor, Elfrieda ; Welker, Ervin
Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants
NUCLEIC ACIDS RESEARCH 46 : 19 pp. 10272-10285. , 14 p. (2018)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
2017
Kulcsár, Péter István ; Tálas, András ; Huszár, Krisztina ; Ligeti, Zoltán ; Toth, Eszter ; Weinhardt, Nóra ; Fodor, Elfrieda ; Welker, Ervin
Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage
GENOME BIOLOGY 18 Paper: 190 , 17 p. (2017)
DOI REAL WoS Scopus PubMed SZTE Publicatio
Article (Journal Article)
Tálas, András ; Kulcsár, Péter István ; Weinhardt, Nóra ; Borsy, Adrienn ; Tóth, Eszter ; Szebényi, Kornélia ; Krausz, Sarah Laura ; Huszár, Krisztina ; Vida, István ; Sturm, Adam ; Gordos, Bianka ; Hoffmann, Orsolya Ivett ; Bencsura, Petra ; Nyeste, Antal ; Ligeti, Zoltán ; Fodor, Elfrieda ; Welker, Ervin
A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid
DNA RESEARCH 24 : 6 pp. 609-621. , 13 p. (2017)
DOI REAL WoS EDIT Scopus PubMed SZTE Publicatio
Article (Journal Article)
2016
Nyeste, Antal ; Stincardini, Claudia ; Bencsura, Petra ; Cerovic, Milica ; Biasini, Emiliano ; Welker, Ervin
The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells.
SCIENTIFIC REPORTS 6 Paper: 36441 , 12 p. (2016)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
Nyeste, Antal ; Bencsura, Petra ; Vida, István ; Hegyi, Zoltán ; Homolya, László ; Fodor, Elfrieda ; Welker, Ervin
Expression of the prion protein family member Shadoo causes drug hypersensitivity that is diminished by the coexpression of the wild type prion protein
JOURNAL OF BIOLOGICAL CHEMISTRY 291 : 9 pp. 4473-4486. , 14 p. (2016)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
Tóth, Eszter ; Weinhardt, Nóra ; Bencsura, Petra ; Huszár, Krisztina ; Kulcsár, Péter István ; Tálas, András ; Fodor, Elfrieda ; Welker, Ervin
Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells
BIOLOGY DIRECT 11 Paper: 46 , 14 p. (2016)
DOI REAL WoS Scopus PubMed SZTE Publicatio
Article (Journal Article)
2015
Cingaram, Pradeep Kumar Reddy ; Nyeste, Antal ; Dondapati, Divya Teja ; Fodor, Elfrieda ; Welker, Ervin
Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu2+, Mn2+, Zn2+ and Co2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity
PLOS ONE 10 : 10 Paper: e0139219 , 20 p. (2015)
DOI WoS Scopus PubMed
Article (Journal Article)
2014
Tóth, Eszter ; Huszár, Krisztina ; Bencsura, Petra ; Kulcsár, Péter István ; Vodicska, Barbara ; Nyeste, Antal ; Welker, Zsombor ; Tóth, Szilvia ; Welker, Ervin
Restriction enzyme body doubles and PCR cloning: on the general use of type IIs restriction enzymes for cloning.
PLOS ONE 9 : 3 Paper: e90896 , 12 p. (2014)
DOI WoS Scopus PubMed
Article (Journal Article)
2013
Orsolits, Barbara ; Borsy, Adrienn ; Madarász, Emilia ; Mészáros, Zsófia ; Kőhidi, Tímea ; Markó, Károly ; Jelitai, Márta ; Welker, Ervin ; Surroundings, Zsuzsanna
Retinoid Machinery in Distinct Neural Stem Cell Populations with Different Retinoid Responsiveness
STEM CELLS AND DEVELOPMENT 22 : 20 pp. 2777-2793. , 17 p. (2013)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
Schäfer, Balázs ; Orbán, Erika ; Borics, Attila ; Huszár, Krisztina ; Nyeste, Antal ; Welker, Ervin ; Tömboly, Csaba
Preparation of semisynthetic lipoproteins with fluorescent cholesterol anchor and their introduction to the cell membrane with minimal disruption of the membrane.
BIOCONJUGATE CHEMISTRY 24 : 10 pp. 1684-1697. , 14 p. (2013)
DOI REAL WoS Scopus PubMed
Article (Journal Article)
Tóth, Eszter ; Kulcsár, Péter István ; Fodor, Elfrieda ; Ayaydin, Ferhan ; Kalmár, Lajos ; Borsy, Adrienn Éva ; Laszlo, Lajos ; Welker, Ervin
The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1833 : 5 pp. 1199-1211. , 13 p. (2013)
DOI REAL WoS Scopus PubMed
Article (Journal Article)