Welker Lab

Sarah Laura Krausz

Postdoc

My research is focused on enhancing the efficiency and precision of prime editing, a cutting-edge CRISPR gene editing technique.

sári_45

Education

2016 - Present
Doctoral school
Molecular Medicine
Semmelweis University (SOTE)

2013 – 2016
Biology MSc
Molecular Genetics, Cell and Developmental Biology specialization
Eötvös Loránd University (ELTE)

2011 – 2016
Eötvös József Collegium

awards and scholarships

2020/2021. Predoctoral scholarship (Semmelweis University) 

2015. Excellent Student of the Faculty award, (ELTE, Faculty of Science)

2014. ELTE Biologist Conference of Scientific Students Associations, molecular biology and physiology category
2nd place

2016. Traineeship , Laboratory of Eukaryotic Molecular Biology (LBME), CNRS Toulouse

2015. Erasmus scholarship for one semester at the Ludwig-Maximilians-Universität München

Publications

Huszár, Krisztina ; Welker, Zsombor ; Györgypál, Zoltán ; Tóth, Eszter ; Ligeti, Zoltán Kulcsár, Péter István ; Dancsó, János ; Tálas, András ; Krausz, Sarah Laura Varga, Éva Ervin Welker
Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs
NUCLEIC ACIDS RESEARCH 51 : 11 pp. 5847-5863. , 17 p. (2023)
DOI   WoS    REAL   Scopus   PubMed
Article (Journal Article)

Kulcsár, Péter István ; Tálas, András ; Ligeti, Zoltán ; Krausz, Sarah Laura ; Welker, Ervin 
SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e
NATURE COMMUNICATIONS 13 : 1 Paper: 6858 , 11 p. (2022)
DOI   WoS    REAL   Scopus   PubMed
Article (Journal Article)

Simon, Dorottya Anna ; Tálas, András ; Kulcsár, Péter István ; Biczók, Zsuzsanna ; Krausz, Sarah Laura Várady, György ; Welker, Ervin
PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully primed edited cells
ELIFE 11 Paper: e69504, 19 p. (2022)
DOI   WoS    REAL   Scopus   PubMed
Article (Journal Article)

Sangeetham, Sangeetham Babu ; Engelke, Anna Dorothee ; Fodor, Elfrieda ; Krausz, Sarah Laura ; Tatzelt, Jörg; Welker, Ervin
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo
SCIENTIFIC REPORTS 11 : 1 Paper: 3116 , 13 p. (2021)
DOI   WoS    REAL   Scopus   PubMed
Article (Journal Article)

Tálas, András ; Simon, Dorottya Anna ; Kulcsár, Péter István ; Varga, Éva ; Krausz, Sarah Laura ; Welker, Ervin
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors
NATURE COMMUNICATIONS 12 : 1 Paper: 6353 , 14 p. (2021)
DOI   WoS    REAL   Scopus   PubMed
Article (Journal Article)

Tóth, Eszter ; Varga, Éva ; Kulcsár, Péter István ; Kocsis-Jutka, Virág ; Krausz, Sarah Laura Nyeste, Antal ; Welker, Zsombor ; Huszár, Krisztina ; Ligeti, Zoltán ; Tálas, András ; Welker, Ervin
Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases
NUCLEIC ACIDS RESEARCH 48 : 7 pp. 3722-3733. , 12 p. (2020)
DOI    REAL   WoS   Scopus   PubMed   Other URLs
Article (Journal Article)

Tóth, Eszter ; Czene, Bernadette C ; Kulcsár, Péter István ; Krausz, Sarah Laura ; Tálas, András ; Nyeste, Antal ; Varga, Éva ; Huszár, Krisztina ; Weinhardt, Nóra ; Ligeti, Zoltán ; Borsy, Adrienn Éva ; Fodor, Elfrieda ; Welker, Ervin
Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants
NUCLEIC ACIDS RESEARCH 46 : 19 pp. 10272-10285. , 14 p. (2018)
DOI    REAL   WoS   Scopus   PubMed
Article (Journal Article)

Tálas, András ; Kulcsár, Péter István ; Weinhardt, Nóra ; Borsy, Adrienn ; Tóth, Eszter ; Szebényi, Kornélia ; Krausz, Sarah Laura ; Huszár, Krisztina ; Vida, István ; Sturm, Ádám ; Gordos, Bianka ; Hoffmann, Orsolya Ivett Bencsura, Petra ; Nyeste, Antal ; Ligeti, Zoltán ; Fodor, Elfrieda ; Welker, Ervin
A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid
DNA RESEARCH 24 : 6 pp. 609-621. , 13 p. (2017)
DOI    REAL   WoS    EDIT   Scopus   PubMed    SZTE Publicatio
Article (Journal Article)