{"id":30,"date":"2020-04-13T11:18:54","date_gmt":"2020-04-13T11:18:54","guid":{"rendered":"https:\/\/welkerlab.hu\/home\/"},"modified":"2026-09-16T16:39:21","modified_gmt":"2026-09-16T14:39:21","slug":"home","status":"publish","type":"page","link":"https:\/\/welkerlab.hu\/en\/","title":{"rendered":"Home"},"content":{"rendered":"
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Featured News<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Our latest publication is out now <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe study of \u00c9va Varga et al. investigates the application of new Cas12a variants in prime editing.<\/span> The work was published in <\/span>the journal Genome Biology.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Our latest publication is out now <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe study of Zsuzsanna Bicz\u00f3ket al. aims to increase the efficiency of prime editing.<\/span> The work was <\/span>published in the journal <\/span>Nucleic Acids Research.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ProPE PLANNER IS NOW AVAILABLE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe ProPE Planner tool, which enables the design of eng- and tpg-RNA pairs, is now available and ready to use.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t2025. 10. 10.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\n\t\t\t\t
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Our latest publication is out now <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe study of Sarah Laura Krausz et al. aims to increase the efficiency of prime editing. The work was published in the journal Nature Catalysis.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t2025. 10. 10.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Our Research Topics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tSince 2013, our research has focused on the nucleases of the CRISPR bacterial \"immune system.\" We are particularly engaged in developing gene-editing systems based on these nucleases, enhancing their efficiency, optimizing their performance, and understanding their mechanisms. Specifically:\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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We are investigating the off-target activity of the SpCas9 nuclease (Nat Commun, 2023<\/a>), and creating a general off-target-free editing protocol.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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We are developing SpCas9 nuclease variants with increased precision (
(Genome Biol, 2017<\/a>;
Nat Commun, 2020<\/a>;
Nat Commun, 2021<\/a>;
Nat Commun, 2022<\/a>)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\tWe are exploring the motif and sequence preferences of SpCas9 nuclease and its variants (Nucleic Acids Res, 2021<\/a>;\u00a0 Nucleic Acids Res, 2023<\/a>)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\tWe are working on understanding, optimizing, and improving prime editing (Nat Catal, 2025<\/a>; Nucleic Acids Res, 2026<\/a>; Genome Biol, 2026<\/a>)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\tWe are continuously developing Cas12a variants that are more efficient and have different PAM binding specificities compared to the wild-type protein (Nucleic Acids Res, 2018<\/a>; Nucleic Acids Res, 2020<\/a>; Genome Biol, 2026<\/a>)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\tFor all of this, we have developed several different, widely applicable reporter systems. Such is the BEAR and PEAR system suitable for testing the effectiveness of base and prime editors (Nat Commun, 2021<\/a>; eLife, 2022<\/a>), as well as the GFxFP reporter system for testing nuclease activity independent of genomic context (Biol Direct, 2016<\/a>)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Our Team<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tMissing from the picture: Margit Dobr\u00e1di, Eszter T\u00f3th, P\u00e9ter T\u00f3th, Luca G\u00e1l\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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News<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Several media reported on \u00c9va Varga's work<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The findings of \u00c9va Varga and her colleagues have been featured across several national professional and media platforms.<\/p>

Qubit<\/a>\u00a0 \u00a0HVG<\/a>\u00a0 \u00a0HUN-REN<\/a>\u00a0 \u00a0<\/em><\/strong><\/span>
HUN-REN TTK<\/em><\/strong><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Preview Article <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A recent article in Bioengineer provides a preview of the work by \u00c9va Varga and her colleagues.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Annual Meeting of the Hungarian Biochemical Society<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Luca G\u00e1l, Bal\u00e1zs Feh\u00e9r, and P\u00e9ter T\u00f3th participated in the Annual Meeting of the Hungarian Biochemical Society and presented their poster.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Genome Engineering: CRISPR Frontiers conference<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tLuca G\u00e1l and Bal\u00e1zs Csoma participated in a conference hosted by the Cold Spring Harbor Laboratory (NY, USA) and presented their research on a poster.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t2026. 08. 11-15.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"diploma-oklevel-002-thumb-thumb-thumb\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Congratulations to our students<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Congratulations to P\u00e9ter T\u00f3th on completing his MSc and his successful admission to the PhD program, and to Bal\u00e1zs Csoma on his admission to the MSc program!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t2026. 07. 30.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"pexels-gentooexpressions-37945360\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Congratulations\non your PhD<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Congratulations to Dorottya Simon and Zsuzsanna Bicz\u00f3k on completing their doctoral degrees!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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2026. 06. 15.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t

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ProPE ON TELEX<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tTelex reported on the findings of our recently published study by Sarah Laura Krausz et al. in an article titled \u201cHungarian Researchers Have Made One of the Most Promising Gene-Editing Methods More Effective.\u201d\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t2025. 10. 21.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\n\t\t\t\t
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We won the NKKP Excellence grant<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tOur project entitled \"Development of new gene editing tools\" received HUF 200 million in funding for two years from the National Research Excellence Program (NKKP).\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t2025. 09. 20.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Kiemelt H\u00edrek Megjelent Leg\u00fajabb publik\u00e1ci\u00f3nk Varga \u00c9va \u00e9s munkat\u00e1rsai munk\u00e1ja \u00faj Cas12a vari\u00e1nsok alkalmaz\u00e1s\u00e1t vizsg\u00e1lja prime editingben. A publik\u00e1ci\u00f3 a Genome Biology foly\u00f3iratban olvashat\u00f3.2026. 08. 28. Megjelent Leg\u00fajabb publik\u00e1ci\u00f3nk Bicz\u00f3k Zsuzsanna \u00e9s munkat\u00e1rsai munk\u00e1ja a prime editing hat\u00e9konys\u00e1g\u00e1nak n\u00f6vel\u00e9s\u00e9t c\u00e9lozza. A publik\u00e1ci\u00f3 a Nucleic Acids Research foly\u00f3iratban jelent meg.2026. 04. 21. EL\u00c9RHET\u0150 A ProPE PLANNER […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-30","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/30","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/comments?post=30"}],"version-history":[{"count":532,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/30\/revisions"}],"predecessor-version":[{"id":3458,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/30\/revisions\/3458"}],"wp:attachment":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/media?parent=30"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}