{"id":2126,"date":"2024-09-09T10:28:42","date_gmt":"2024-09-09T08:28:42","guid":{"rendered":"https:\/\/welkerlab.hu\/?page_id=2126"},"modified":"2026-02-06T11:18:02","modified_gmt":"2026-02-06T10:18:02","slug":"krausz-sarah-laura","status":"publish","type":"page","link":"https:\/\/welkerlab.hu\/en\/krausz-sarah-laura\/","title":{"rendered":"Sarah Laura Krausz"},"content":{"rendered":"
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Sarah Laura Krausz<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Postdoc<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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My research is focused on enhancing the efficiency and precision of prime editing, a cutting-edge CRISPR gene editing technique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Education<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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2016 - Present<\/em>
Doctoral school
Molecular Medicine<\/em>
<\/strong>Semmelweis University (SOTE)<\/p>

2013 – 2016<\/em>
Biology MSc
Molecular Genetics, Cell and Developmental Biology specialization<\/em>
<\/strong>E\u00f6tv\u00f6s Lor\u00e1nd University (ELTE)<\/p>

2011 – 2016<\/em>
E\u00f6tv\u00f6s J\u00f3zsef Collegium
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awards and scholarships<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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2020\/2021. Predoctoral scholarship (Semmelweis University)\u00a0<\/p>

2015. Excellent Student of the Faculty award, (ELTE, Faculty of Science)<\/p>

2014. ELTE Biologist Conference of Scientific Students Associations, molecular biology and physiology category
2nd place<\/em><\/p>

2016. Traineeship , Laboratory of Eukaryotic Molecular Biology (LBME), CNRS Toulouse<\/p>

2015. Erasmus scholarship for one semester at the Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Husz\u00e1r, Krisztina\u00a0<\/a>; Welker, Zsombor ;\u00a0Gy\u00f6rgyp\u00e1l, Zolt\u00e1n<\/a>\u00a0;\u00a0T\u00f3th, Eszter<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n\u00a0<\/a>;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n\u00a0<\/a>; Dancs\u00f3, J\u00e1nos ;\u00a0T\u00e1las, Andr\u00e1s\u00a0<\/a>;\u00a0Krausz, Sarah Laura\u00a0<\/a><\/strong>;\u00a0Varga, \u00c9va\u00a0<\/a>;\u00a0Ervin Welker<\/a>
Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 51 : 11 pp. 5847-5863. , 17 p. (2023)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a><\/strong>\u00a0;\u00a0Welker, Ervin\u00a0<\/a>
SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e<\/a><\/em><\/span>
NATURE COMMUNICATIONS 13 : 1 Paper: 6858 , 11 p. (2022)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

Simon, Dorottya Anna<\/a>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Bicz\u00f3k, Zsuzsanna<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a>\u00a0<\/strong>;\u00a0V\u00e1rady, Gy\u00f6rgy<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully primed edited cells<\/a><\/em><\/span>
ELIFE 11 Paper: e69504, 19 p. (2022)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

Sangeetham, Sangeetham Babu<\/a>\u00a0; Engelke, Anna Dorothee ;\u00a0Fodor, Elfrieda<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a>\u00a0<\/strong>; Tatzelt, J\u00f6rg;\u00a0Welker, Ervin<\/a>
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo<\/a><\/em><\/span>
SCIENTIFIC REPORTS 11 : 1 Paper: 3116 , 13 p. (2021)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Simon, Dorottya Anna<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a><\/strong>\u00a0;\u00a0Welker, Ervin<\/a>
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors<\/a><\/em><\/span>
NATURE COMMUNICATIONS 12 : 1 Paper: 6353 , 14 p. (2021)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00f3th, Eszter<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0; Kocsis-Jutka, Vir\u00e1g ;\u00a0Krausz, Sarah Laura<\/a>\u00a0<\/strong>;\u00a0Nyeste, Antal<\/a>\u00a0; Welker, Zsombor ;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 48 : 7 pp. 3722-3733. , 12 p. (2020)
DOI\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed\u00a0 \u00a0<\/a>Other URLs<\/a>
Article (Journal Article)<\/p>

T\u00f3th, Eszter<\/a>\u00a0; Czene, Bernadette C ;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a><\/strong>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Nyeste, Antal<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a>\u00a0;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Weinhardt, N\u00f3ra<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0Borsy, Adrienn \u00c9va<\/a>\u00a0;\u00a0Fodor, Elfrieda<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 46 : 19 pp. 10272-10285. , 14 p. (2018)
DOI\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Weinhardt, N\u00f3ra<\/a>\u00a0;\u00a0Borsy, Adrienn<\/a>\u00a0;\u00a0T\u00f3th, Eszter<\/a>\u00a0;\u00a0Szeb\u00e9nyi, Korn\u00e9lia<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a><\/strong>\u00a0;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Vida, Istv\u00e1n<\/a>\u00a0;\u00a0Sturm, \u00c1d\u00e1m<\/a>\u00a0; Gordos, Bianka ;\u00a0Hoffmann, Orsolya Ivett\u00a0<\/a>;\u00a0Bencsura, Petra<\/a>\u00a0;\u00a0Nyeste, Antal<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0Fodor, Elfrieda<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
A convenient method to pre-screen candidate guide RNAs for CRISPR\/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid<\/a><\/em><\/span>
DNA RESEARCH 24 : 6 pp. 609-621. , 13 p. (2017)
DOI\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0EDIT\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed\u00a0 \u00a0<\/a>\u00a0SZTE Publicatio<\/a>
Article (Journal Article)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Krausz Sarah Laura Postdoc A kutat\u00e1som k\u00f6zponti t\u00e9m\u00e1ja a prime editing, az egyik legmodernebb CRISPR g\u00e9nszerkeszt\u00e9si m\u00f3dszer hat\u00e9konys\u00e1g\u00e1nak \u00e9s precizit\u00e1s\u00e1nak tov\u00e1bbfejleszt\u00e9se. Tanulm\u00e1nyok 2016 – jelenlegDoktori iskolaMolekul\u00e1ris Orvostudom\u00e1nyok tagozatSemmelweis Egyetem (SOTE) 2013 – 2016Biol\u00f3gia MScMolekul\u00e1ris Genetika, Sejt- \u00e9s Fejl\u0151d\u00e9sbiol\u00f3gia szakir\u00e1nyE\u00f6tv\u00f6s Lor\u00e1nd Tudom\u00e1nyegyetem (ELTE) 2011 – 2016E\u00f6tv\u00f6s J\u00f3zsef Collegium d\u00edjak \u00e9s \u00f6szt\u00f6nd\u00edjak 2020\/2021. Predoktori \u00f6szt\u00f6nd\u00edj (Semmelweis Egyetem)\u00a0 […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2126","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/comments?post=2126"}],"version-history":[{"count":58,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2126\/revisions"}],"predecessor-version":[{"id":3075,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2126\/revisions\/3075"}],"wp:attachment":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/media?parent=2126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}