{"id":2076,"date":"2024-09-09T08:27:54","date_gmt":"2024-09-09T06:27:54","guid":{"rendered":"https:\/\/welkerlab.hu\/?page_id=2076"},"modified":"2024-10-14T12:28:39","modified_gmt":"2024-10-14T10:28:39","slug":"varga-eva","status":"publish","type":"page","link":"https:\/\/welkerlab.hu\/en\/varga-eva\/","title":{"rendered":"\u00c9va Varga"},"content":{"rendered":"
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\u00c9va Varga<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Predoc<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The focus of my research topic is the Cas12a (formerly known as Cpf1) protein belonging to the CRISPR-Cas system. It is an excellent alternative to the widely recognized Cas9 protein, offering enhanced effectiveness for specific applications due to its unique properties. However, like all systems, it does have its limitations. I am actively working to minimize these limitations to expand its potential for broader and more effective use.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Education<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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2018 - Present<\/em>
Doctoral school
Multidisciplinary Medical Sciences<\/em>
<\/strong>University of Szeged (SZTE)<\/p>

2018<\/em>
Biology MSc
Molecular, Immune and Microbiology specialization<\/em>
<\/strong>E\u00f6tv\u00f6s Lor\u00e1nd University (ELTE)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Research Interest<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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My primary interest lies in the treatment of genetic diseases, which inspired me to focus on the development of the CRISPR system. I aspire to contribute to something meaningful, enhancing both the field and my own utility in it. The CRISPR system has proven, especially in recent years, to offer solutions for many previously untreatable diseases and to improve patients' quality of life. Therefore, advancing this technology is crucial for its widespread application. Alongside my colleagues, I have participated in numerous related projects, with my work on Cas12a proteins being particularly significant to me. I thoroughly enjoy laboratory work, especially cell manipulation, but I also find the analysis of next-generation sequencing (NGS) data to be both fascinating and enjoyable.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Husz\u00e1r, Krisztina\u00a0<\/a>; Welker, Zsombor ;\u00a0Gy\u00f6rgyp\u00e1l, Zolt\u00e1n<\/a>\u00a0;\u00a0T\u00f3th, Eszter<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n\u00a0<\/a>;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n\u00a0<\/a>; Dancs\u00f3, J\u00e1nos ;\u00a0T\u00e1las, Andr\u00e1s\u00a0<\/a>;\u00a0Krausz, Sarah Laura\u00a0<\/a>;\u00a0Varga, \u00c9va<\/strong>\u00a0<\/a>;\u00a0Ervin Welker<\/a>
Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 51 : 11 pp. 5847-5863. , 17 p. (2023)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Simon, Dorottya Anna<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a><\/strong>\u00a0;\u00a0Krausz, Sarah Laura<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors<\/a><\/em><\/span>
NATURE COMMUNICATIONS 12 : 1 Paper: 6353 , 14 p. (2021)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Varga, Julia K<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a>\u00a0<\/strong>;\u00a0T\u00f3th, Eszter<\/a>\u00a0; Welker, Zsombor ; Erd\u0151s, Gergely ;\u00a0Pach, P\u00e9ter Ferenc<\/a>\u00a0; Welker, Agnes ;\u00a0Gy\u00f6rgyp\u00e1l, Zolt\u00e1n<\/a>\u00a0;\u00a0Tusn\u00e1dy, G\u00e1bor<\/a>\u00a0;\u00a0Welker, Ervin<\/a>\u00a0
A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 49 : 6 Paper: e31 , 12 p. (2021)
DOI\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>

T\u00f3th, Eszter<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a><\/strong>\u00a0;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0; Kocsis-Jutka, Vir\u00e1g ;\u00a0Krausz, Sarah Laura<\/a>\u00a0;\u00a0Nyeste, Antal<\/a>\u00a0; Welker, Zsombor ;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 48 : 7 pp. 3722-3733. , 12 p. (2020)
DOI\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed\u00a0 \u00a0<\/a>Other URLs<\/a>
Article (Journal Article)<\/p>

T\u00f3th, Eszter<\/a>\u00a0; Czene, Bernadette C ;\u00a0Kulcs\u00e1r, P\u00e9ter Istv\u00e1n<\/a>\u00a0;\u00a0Krausz, Sarah Laura<\/a>\u00a0;\u00a0T\u00e1las, Andr\u00e1s<\/a>\u00a0;\u00a0Nyeste, Antal<\/a>\u00a0;\u00a0Varga, \u00c9va<\/a><\/strong>\u00a0;\u00a0Husz\u00e1r, Krisztina<\/a>\u00a0;\u00a0Weinhardt, N\u00f3ra<\/a>\u00a0;\u00a0Ligeti, Zolt\u00e1n<\/a>\u00a0;\u00a0Borsy, Adrienn \u00c9va<\/a>\u00a0;\u00a0Fodor, Elfrieda<\/a>\u00a0;\u00a0Welker, Ervin<\/a>
Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants<\/a><\/em><\/span>
NUCLEIC ACIDS RESEARCH 46 : 19 pp. 10272-10285. , 14 p. (2018)
DOI\u00a0 \u00a0<\/a>\u00a0REAL\u00a0 \u00a0<\/a>WoS\u00a0 \u00a0<\/a>Scopus\u00a0 \u00a0<\/a>PubMed<\/a>
Article (Journal Article)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Varga \u00c9va Predoc Kutat\u00e1si t\u00e9m\u00e1m k\u00f6z\u00e9ppontj\u00e1ban a CRISPR-Cas rendszerhez tartoz\u00f3 Cas12a (kor\u00e1bbi nev\u00e9n Cpf1) feh\u00e9rje \u00e1ll. Ez a legismertebb Cas9 feh\u00e9rje remek alternat\u00edv\u00e1ja, mivel elt\u00e9r\u0151 tulajdons\u00e1gainak k\u00f6sz\u00f6nhet\u0151en bizonyos alkalmaz\u00e1sokban hat\u00e9konyabban haszn\u00e1lhat\u00f3. Mint minden rendszernek, ennek is megvannak a limit\u00e1ci\u00f3i, ezeket pr\u00f3b\u00e1lom cs\u00f6kkenteni, hogy m\u00e9g sz\u00e9lesk\u00f6r\u0171bben \u00e9s effekt\u00edvebben lehessen alkalmazni. Linkedin Tanulm\u00e1nyok 2018 – jelenlegDoktori iskolaMultidiszciplin\u00e1ris […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2076","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/comments?post=2076"}],"version-history":[{"count":16,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2076\/revisions"}],"predecessor-version":[{"id":2623,"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/pages\/2076\/revisions\/2623"}],"wp:attachment":[{"href":"https:\/\/welkerlab.hu\/en\/wp-json\/wp\/v2\/media?parent=2076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}